Reply to "Prognostic Value of Fluorodeoxyglucose-Positron Emission Tomography".

نویسندگان

  • Woocheol Kwon
  • Brandon A Howard
  • James E Herndon
  • Edward F Patz
چکیده

e102 Journal of Thoracic Oncology ® • Volume 10, Number 10, October 2015 importance of the T-stage and have reanalyzed our primary data. By analysis of variance and the Wilcoxon rank sum test, we show that the distribution of maximum standardized uptake value (SUV max ) within the three “T” groups (T1a/T1b/T2a) is significantly different (p < 0.0001). Cox proportional hazards model was then used to assess the relationship between T-stage and survival with and without adjustment for SUV max (uncategorized). After adjustment for T-stage, the effect of SUV max remains statistically significant (p = 0.003). In our study, the effect of T-stage was not a statistically significant predictor of survival with or without adjustment for SUV max . The lack of statistical significance for T-stage does not necessarily imply that the variable does not have prognostic importance. Rather, the power of this statistical analysis may be limited by there being only 134 deaths, which in general drives the power of a study to detect a clinically meaningful effect. As we suggested, prospective treatment trials in early-stage disease could incorporate SUV max to stratify patients for therapy, although we acknowledge that other features including T-stage need to be considered.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Background-Based Delineation of Internal Tumor Volumes on Static Positron Emission Tomography in a Phantom Study

Objective(s): Considering the fact that the standardized uptake value (SUV) of a normal lung tissue is expressed as x±SD, x+3×SD could be considered as the threshold value to outline the internal tumor volume (ITV) of a lung neoplasm. Methods: Three hollow models were filled with 55.0 kBq/mL fluorine18- fluorodeoxyglucose (18F-FDG) to represent tumors. The models were fixed to a barrel filled w...

متن کامل

Predictive ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography for pathological complete response and prognosis after neoadjuvant chemotherapy in triple-negative breast cancer patients

Objective The mortality of patients with locally advanced triple-negative breast cancer (TNBC) is high, and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is associated with improved prognosis. This retrospective study was designed and powered to investigate the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict pat...

متن کامل

The effect of fasting on Positron Emission Tomography (PET) imaging

As a nuclear approach, Positron Emission Tomography (PET) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. There are certain limitations to this technique such as normal tissue uptake. Therefore, it has been recommended that patients prepare before scanning. Fasting for a short while before PET imaging is an exampl...

متن کامل

Prognostic value of various metabolic parameters on pre-treatment 18-F-FDG PET/CT in patients with stage I-III non-small cell lung cancer

Background: the aim of this study was to investigate the prognostic value of 18Fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) parameters in both overall survival and progression-free survival in Stage I-III non-small cell lung cancer (NSCLC). Materials and Methods: In this retrospective study, 267 patients who were diagnosed as Stage I-III non-smal...

متن کامل

Diagnostic Accuracy of Positron Emission Mammography with 18F-fluorodeoxyglucose in Breast Cancer Tumor of Less than 20 mm in Size

Objective(s): To investigate the diagnostic accuracy of positron emission mammography (PEM) and positron emission tomography/computed tomography (PET/CT) for small breast tumors of less than 20 mm in size.Methods: The study was conducted on a total of 100 subjects (i.e., 50 patients with pathologically proven breast cancer and 50 normal cases of medical screening). The total number of tumors wa...

متن کامل

Early metabolic response evaluation after stereotactic radiotherapy for lung cancer: pilot experience with 18F-fluorodeoxyglucose positron emission tomography-computed tomography.

The early response of lung tumours to stereotactic radiotherapy was prospectively evaluated with 18F-fluorodeoxyglucose positron emission tomography-computed tomography. Three months after treatment, the maximum standardised uptake value and the tumour diameter fell by 64 and 30%, respectively. This imaging strategy therefore remains under ongoing evaluation with the aim of identifying predicti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

دوره 10 10  شماره 

صفحات  -

تاریخ انتشار 2015